Preface—Anticancer Drugs from Marine Origin
نویسنده
چکیده
Over the years, the invention of new compounds are isolated by using advanced technology has expanded significantly. There are number of compounds developed from marine environment for the treatment of various diseases. Increasing evidence suggested that anticancer drug discovery leads from the marine environment. This book combines the knowledge about the compounds isolated from marine environment and their product development. This handbook is divided into five parts. Chapter 1 provides general introduction and sponges, seaweed, microbes, tuni-cates and other miscellaneous compounds derived from marine organisms. Part I—Sponges (Chaps. 2–6), described the sponge derived drugs represent one of the most promising sources of research for finding new anticancer drugs. These chapters discusses about the anticancer and angiogenesis inhibitors isolated from marine sponges and mechanism of action and preclinical and clinical studies. Part II—About the marine algae derived compounds on cancer targets (Chaps. 6–11)—explained the compounds isolated from algae species, amelioration and anti tumor effect of a tertiary sulfonium compound, dimethylsulfoniopropio-nate, carotenoids, polysaccharides etc and the possible mechanisms of action are described. Also the health benefits of seaweeds biological roles and potential benefits for female cancers to be discussed in this part. Part III—Provides (Chaps. 12–17) the details about marine microbial derived compounds for cancer therapeutics. The antitumor compounds isolated from marine microbes such as fungi, bacteria and actinobacteria are discussed. Part IV—Discusses (Chap. 18) with marine tunicate derived compounds for cancer therapeutics. Part V—The final part of the book covers others marine organisms derived compounds and mechanism of actions. In this part sources of the marine compounds, pyridoacridine alkaloids, triterpene glycosides, meroterpenoids for cancer targets such as microtubules, apoptosis, angiogenesis and also discovery and computer-aided drug design studies of the anticancer marine triterpene sipholanes as novel P-gp and Brk modulators to be discussed in these chapters. This book provides details about compounds isolation, chemistry, and application in detail. Hence, anticancer drugs from marine origin are important for academic research, pharmaceutical, nutraceutical and biomedical industries. I would
منابع مشابه
Natural products of marine origin and their perspectives in the discovery of new anticancer drugs
Marine invertebrates and a growing number of marine actinomycetes are the sources of novel, bioactive secondary metabolites. This review is presented as a short survey of recent investigations in the marine pharmacology and discovery of new anticancer drugs. The implications of this research towards the development of marine secondary metabolites as a sustainable source of new drugs are discussed.
متن کاملIn vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species
Breast cancer is the most common cancer type among women all over the world. Chemotherapy is the use of anticancer medicines for treating cancer but it has many side effects and cells may become resistant to these chemical medicines. Therefore, finding new compounds of natural origin could be a promising solution to this problem. The aim of the current study was to evaluate anticancer activity ...
متن کاملAlkaloids from marine invertebrates as important leads for anticancer drugs discovery and development.
The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerni...
متن کاملA survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2011.
Cancer continues to be a major public health problem despite the efforts that have been made in the search for novel drugs and treatments. The current sources sought for the discovery of new molecules are plants, animals and minerals. During the past decade, the search for anticancer agents of marine origin to fight chemo-resistance has increased greatly. Each year, several novel anticancer mol...
متن کاملMarine natural products as anticancer drugs.
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in st...
متن کامل